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Butterbur is an herb native to Europe, south western Asia, and north Africa. The leaf and root extracts of Butterbur have been used to treat allergies, bronchial asthma, headache, pain, and muscle and urinary tract spasms. Petasins, the sesquiterpene compounds found in Butterbur, are thought to be the active constituents.

Leaf and root extracts of Butterbur are effective in controlling migraines in adults and in children and asthma. Butterbur extract may also be effective against somatoform disorders.
But results from studies on allergic diseases are mixed. Some studies suggest the efficacy of Butterbur extract is comparable to standard antihistamine drugs for allergic rhinitis but conflicting data indicate that it is no better than placebo for intermittent rhinitis or for allergic skin disease. A systematic review of trials suggests the need for more rigorous studies before recommending use of Butterbur.
Raw butterbur extract may contain excessive toxic pyrrolizidine alkaloids that can cause liver damage.